During Murine Madness Month, NanoString is hosting a variety of activities such as webinars with special guest speakers sharing their mouse research, a scavenger hunt and more! We invite you to join us for different events to be entered into our raffle to win prizes!
Webinar Series
Join us for our Webinar Series! Each webinar will focus on the integration of nCounter® and GeoMx® Digital Spatial Profiling approaches to mouse model research. Learn how the field is advancing with the insights gained from bulk analysis combined with spatial resolution.
Genetics of Osteoarthritis: From Man to Fish to Mouse
Michael J. Jurynec, PhD, University of Utah

Hear how Dr. Jurynec approaches the discovery of osteoarthritis (OA) susceptibility genes using genetics and gene expression analysis, from using both zebrafish and mouse models to test the functional impact of candidate variants to using a mouse model to understand the impact of human variants on the onset and progression of OA.
Using mice to unravel the mysteries of COVID-19 disease
Nadia Rosenthal, The Jackson Laboratory

The JAX/RML teams are working to create refined COVID-19 mouse models for future research to uncover the interplay between the virus and the host’s immune reactions, to establish predictive biomarkers of disease severity and targets for treatment, and to gain greater insight into the genetic architecture underlying disease risk and progression.
Anatomical analysis of infection in the brain
Emma Wilson, PhD, University of California, Riverside

Presenting a wide-ranging study on Toxoplasma-induced changes in RNA and protein in the infected brain over the course of infection. Using brain samples from infected and uninfected mice, genes associated with neuropathology and neuroinflammation.
NanoString Transcriptomic Analysis of Murine Models of Retinitis Pigmentosa-59
Steven J. Fliesler, PhD, University at Buffalo and VA Western NY Healthcare System & Steven J. Pittler, PhD, University of Alabama at Birmingham (UAB)

We recently developed genetically modified mouse models of RP59 and characterized their phenotypes. In an effort to elucidate the molecular mechanism(s) underlying the observed retinal phenotypes we performed a detailed transcriptomic analysis of the retinas from each of these mouse models using the NanoString® nCounter® Analysis System and compared it to that of wild type controls on a congenic (C57BL/6J) background.
Contextual reprogramming of CAR-T cells for the treatment of HER2-expressing cancers
THURSDAY, March 25, 2021, 2 PM SGT
Zhifen Yang, PhD, Refuge Biotechnologies

In this webinar, we present a conditional, antigen encounter-dependent CRISPR interference (CRISPRi)-modulation circuit (RB-340-1) that promotes CAR-T resilience to checkpoint suppression, extending in vivo persistence and effectiveness. 
Characterizing Late-Onset AD Models Using Spatial Whole Transcriptome Analysis
TUESDAY, March 30, 2021, 2 PM SGT
Gregory Carter, PhD, The Jackson Laboratory

Utilizing a precommercial version of nanoString’s GeoMx® Mouse Whole Transcriptome Atlas (WTA) content, we analyzed the entire mouse transcriptome throughout the cortex and hippocampus of the B6.APOEe4.Trem2*R47H/hAβ mouse strain at multiple time points (12-16 months of age).
Find that Mouse!
Keep your eyes peeled as you browse the NanoString website for hidden mice! Find 5 or more to win NanoString swag. Find 15 to enter to win 24 samples of your choice of an nCounter mouse gene expression panel.
HINT: Mouse #1 is hidden on the Host Response Panel page .
Do you have Budding Scientists at home?
Share their Big Cheese artwork with these mouse themed colouring sheets for extra fun. Be sure to share your artwork with us on Social Media!